Fellow in Medicine, Harvard Medical School (1986–1988); Instructor in Medicine, Harvard Medical School (1988–1989); Pioneered and Head, Molecular Genetics Unit (1989 – then transitioned to Co-Head, Cancer Genetics in 2010 – current), Co-Head of the Kolling Institute of Medical Research (1989–); Professor of Medicine (Endocrinology), University of Sydney (1992); Head, Department of Medicine, University of Sydney, Northern Clinical School (1996–2001); Chairman, Department of Medicine, University of Sydney (1998–1999); Head, Division of Medicine, Royal North Shore Hospital (1998–2006); Chairman, Hoc Mai, Australia Vietnam Medical Foundation, University of Sydney (2001–); Associate Dean (International) Faculty of Medicine, University of Sydney (2003–2005); Dean, Faculty of Medicine, University of Sydney (2006–2016); awarded Member AM (2012) on Queen’s Birthday Honours, Chair, National Health and Medical Research Scientific Council (2015 – current); Chair, Medicare Benefits Schedule (MBS) Review Taskforce (2015 – current); Director, Cochlear Limited (2017 - current); Director, Mayne Pharma Group Limited (2014 - current); Director QBiotics Group Ltd (2018 – current), Director Ecofibre Pty Ltd (2021 – current).

In 2020 Bruce was awarded the Companion (AC) in the General Division of the Order of Australia.

Appointed 30 May 2006